LightCycler assay in the analysis of haplotypes of the type 2 diabetes susceptibility gene CAPN10.
نویسندگان
چکیده
Type 2 Diabetes Susceptibility Gene CAPN10, Heike Görgens, Peter Schwarz, Jan Schulze, Hans K. Schackert (Departments of 1 Surgical Research and 2 Endocrinopathies and Metabolic Diseases, Universitätsklinikum Carl Gustav Carus, Dresden, University of Technology, Fetscherstra e 74, D-01307 Dresden, Germany; 3 these authors contributed equally to this project; *author for correspondence; fax 49-351-458-4350, e-mail [email protected])
منابع مشابه
Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.
Variation within the calpain-10 gene (CAPN10) has been proposed to account for linkage to type 2 diabetes on chromosome 2q in Mexican-Americans, and associations with diabetes have been reported in several other populations. Given the epidemiological, physiological, and genetic overlap between type 2 diabetes and polycystic ovary syndrome (PCOS), CAPN10 represents a strong candidate gene for a ...
متن کاملRole of calpain-10 gene variants in familial type 2 diabetes in Caucasians.
The calpain-10 gene (CAPN10) has been implicated in type 2 diabetes (T2DM) susceptibility by both linkage and association in a Hispanic population from Starr County Texas. Common intronic variants seem to alter CAPN10 mRNA levels and were associated with insulin resistance but not diabetes in Pima Indians. The role of these variants in Caucasian populations is less clear. We found some evidence...
متن کاملVariants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels.
The calpain-10 gene (CAPN10) has been associated with type 2 diabetes, but information on molecular and physiological mechanisms explaining this association is limited. Here we addressed this question by studying the role of CAPN10 for phenotypes associated with type 2 diabetes and free fatty acid (FFA) metabolism. Among 395 type 2 diabetic patients and 298 nondiabetic control subjects from Fin...
متن کاملGeographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
Recently, a positional cloning study proposed that haplotypes at the calpain-10 locus (CAPN10) are associated with increased risk of type 2 diabetes, or non-insulin-dependent diabetes mellitus, in Mexican Americans, Finns, and Germans. To inform the interpretation of the original mapping results and to look for evidence for the action of natural selection on CAPN10, we undertook a population-ba...
متن کاملCommon genetic variation in calpain-10 gene (CAPN10) and diabetes risk in a multi-ethnic cohort of American postmenopausal women.
Calpain-10 (CAPN10) protein may play a role in glucose metabolisms, pancreatic beta-cell insulin secretion and thermogenesis. Emerging evidence has implicated a role of CAPN10 genetic variants in the risk of type 2 diabetes mellitus (T2DM). Previous association studies, however, have focussed only on several variants initially reported and provided inconsistent results. We conducted a large nes...
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عنوان ژورنال:
- Clinical chemistry
دوره 49 8 شماره
صفحات -
تاریخ انتشار 2003